Annals of Saudi Medicine
Publication of the King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Users Online: 18 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Home  About us   Issues     Search     Subscribe   Contact   
Year : 2009  |  Volume : 29  |  Issue : 6  |  Page : 450-453

Renal biopsy in patients with type 2 diabetes mellitus: Indications and nature of the lesions

1 Nephrology Unit, Mubarak Al Kabeer Hospital, Kuwait
2 Department of Histopathology, Mubarak Al Kabeer Hospital, Kuwait
3 Nephrology Unit, Jahra Hospital, Ministry of Health, Kuwait

Correspondence Address:
Amal Abdel Ghani
Nephrology Unit, Mubarak Al Kabeer Hospital, PO Box , Code 3205, Hawally

DOI: 10.4103/0.

Get Permissions

Background and Objectives : The prevalence of non diabetic renal disease (NDRD) among patients with type 2 diabetes mellitus varies widely depending on the selection criteria and the populations being studied. The aim of this study was to evaluate the renal biopsies performed on type 2 diabetic patients for suspicion of NDRD and to correlate the pathological with the clinical and laboratory findings. Subjects and Methods : We selected and reviewed biopsies performed on type 2 diabetics for clinically suspected NDRD from January 2006 to December 2008 at a single hospital. Clinical and laboratory data were analyzed in relation to the histopathology findings. Patients were grouped into either group I with isolated DGS or group II with NDRD on top of DGS. Results : Thirty-one biopsies were performed on type 2 diabetic patients; Seventeen patients (54.8%) were males. Mean age was 50.68 (11.29) years. The mean duration of diabetes was 9.33 (3.6) years. Renal biopsy showed that among the studied group 14 patients (45.2%) showed NDRD on top of DGS. Crescentic glomerulonephritis was the commonest finding seen in 3 cases (21.4% of group II cases) followed by acute tubulointerstitial nephritis and hypertensive changes each was seen in 2 cases (14.4%). Other findings included IgA nephropathy, primary focal segmental glomerulosclerosis, rhabdomyolysis, membranoproliferative glomerulonephritis each of them was seen in one case (7.1%). Group I had a significantly higher level of proteinuria 4.97 (2.08) gm/24 hrs urine than group II 2.72 (1.09) gm/24 hrs urine (P=.003). There was no significant difference between the two groups in age, duration of diabetes, gender, presence of hypertension, hematuria, serum creatinine or glomerular filtration rate. Conclusion : The present study showed that crescentic glomerulonephritis is the commonest NDRD among diabetic patients. A higher level of proteinuria was reported among those with NDRD superimposed on DGS. So, Renal biopsy should be performed in diabetics when the clinical scenario is atypical.

Print this article    
 Next Article
 Previous Article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
  • Ghani AA
  • Al Waheeb S
  • Al Sahow A
  • Hussain N
   Search Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    Viewed 253    
    Printed 5    
    Emailed 0    
    PDF Downloaded 134    
    Comments  [Add]    

Recommend this journal