Annals of Saudi Medicine
Publication of the King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Users Online: 14 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Home  About us   Issues     Search     Subscribe   Contact    Login 
 
ORIGINAL ARTICLE
Year : 2010  |  Volume : 30  |  Issue : 2  |  Page : 101-108

Candidal colonization, strain diversity, and antifungal susceptibility among adult diabetic patients


 Department of Oral Basic and Clinical Sciences, King Abdul Aziz University Faculty of Dentistry, Jeddah, Saudi Arabia

Correspondence Address:
Safia A Al-Attas
King Abdul Aziz University Faculty of Dentistry, PO Box 7467, Khawlah Bint Malik, Al-Fayhaa Unit Number 1, 22246-3953 Jeddah
Saudi Arabia
Login to access the Email id
DOI: 10.4103/0256-4947.60514

PMID: 20220258



Get Permissions

Background and Objectives : Candidal colonization in diabetics is a matter of debate. The aim of this study is to investigate oral candidal colonization, strain diversity, antifungal susceptibility, and the influence of local and systemic host factors on candidal colonization in adult diabetics. Methods : We conducted a case-control study that compared 150 diabetics (49 type 1, 101 type 2) with 50 healthy controls. Two salivary samples were collected, using the oral rinse sampling method: one for salivary flow rate and pH determination, and the other for candidal colonization assessment. The candidal isolates were identified and tested in vitro for antifungal susceptibility using the commercial kit, Candifast. The relationship between specific host factors and candidal colonization was also investigated. Results : Diabetics had a higher candidal carriage rate compared to controls, but not density. Candida albicans was the most frequently isolated species, but diabetics had a variety of other candidal species present. None of the control samples were resistant to any tested antifungal, while the diabetic samples had differing resistances to azole antifungals. Although there was a significant positive correlation between glycemic control and candidal colonization in type 2 diabetics, there was a negative correlation between salivary pH and candidal carriage in the controls versus density in type 2 diabetics. Conclusions : Diabetic patients not only had a higher candidal carriage rate, but also a variety of candidal species that were resistant to azole antifungals. Oral candidal colonization was significantly associated with glycemic control, type of diabetes, and salivary pH.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next Article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed391    
    Printed24    
    Emailed0    
    PDF Downloaded222    
    Comments [Add]    

Recommend this journal